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COL22A1

GENERAL INFORMATION

Gene name

 COL22A1

Gene description

 Collagen, type XXII, alpha 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland)
GTEx:Tissue enriched (pituitary gland)
FANTOM5:Group enriched (epididymis, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA024830
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, pituitary gland)

GENE INFORMATION

Gene name

 COL22A1

Synonyms

Description

 Collagen, type XXII, alpha 1 (HGNC Symbol)

Entrez gene summary

 COL22A1, a member of the FACIT (fibrillar-associated collagens with interrupted triple helices) subgroup of the collagen protein family, specifically localizes to tissue junctions (Koch et al., 2004 [PubMed 15016833]).[supplied by OMIM, Mar 2008]

Chromosome

 8

Cytoband

Chromosome location (bp)

 138588235 - 138914006

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169436 (version 83.38)

Entrez gene

 169044

UniProt

 Q8NFW1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NFW1

Antibodypedia

 COL22A1 antibodies

PROTEIN BROWSER
COL22A1-001
COL22A1-007
COL22A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COL22A1-001
ENSP00000303153
ENST00000303045
Q8NFW1 [Direct mapping]
Collagen alpha-1(XXII) chain
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005788 [endoplasmic reticulum lumen]
GO:0030198 [extracellular matrix organization]
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 1626 aa
161.1 kDa 		Yes 0
COL22A1-007
ENSP00000428244
ENST00000522546
H0YAX7 [Direct mapping]
Collagen alpha-1(XXII) chain
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Predicted intracellular proteins
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 65 aa
6.2 kDa 		No 0
COL22A1-201
ENSP00000387655
ENST00000435777
Q8NFW1 [Direct mapping]
Collagen alpha-1(XXII) chain
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005788 [endoplasmic reticulum lumen]
GO:0030198 [extracellular matrix organization]
Show all
 1319 aa
129.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.