Expression of SPRR1A in cancer - Summary - The Human Protein Atlas

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SPRR1A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPRR1A
Gene description	Small proline-rich protein 1A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Group enriched (HaCaT, hTCEpi, RT4)
HPA (normal tissue):	Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB011237
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB011237

GENE INFORMATION
Gene name	SPRR1A
Synonyms
Description	Small proline-rich protein 1A (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	152985231 - 152985500
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169474 (version 83.38)
Entrez gene	6698
UniProt	P35321 (UniProt - Evidence at protein level)
neXtProt	NX_P35321
Antibodypedia	SPRR1A antibodies

PROTEIN BROWSER

SPRR1A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPRR1A-001 ENSP00000357751 ENST00000368762	P35321 [Direct mapping] Cornifin-A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001533 [cornified envelope] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008544 [epidermis development] GO:0018149 [peptide cross-linking] GO:0030216 [keratinocyte differentiation] GO:0030674 [protein binding, bridging] GO:0031424 [keratinization] Show all	89 aa 9.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.