Expression of HTRA4 in cancer - Summary - The Human Protein Atlas

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HTRA4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HTRA4
Gene description	HtrA serine peptidase 4
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA045402
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045402

GENE INFORMATION
Gene name	HTRA4 (HGNC Symbol)
Synonyms	FLJ90724
Description	HtrA serine peptidase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
Chromosome	8
Cytoband	p11.22
Chromosome location (bp)	38974164 - 38988662
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169495 (version 83.38)
Entrez gene	203100
UniProt	P83105 (UniProt - Evidence at transcript level)
neXtProt	NX_P83105
Antibodypedia	HTRA4 antibodies

PROTEIN BROWSER

HTRA4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTRA4-001 ENSP00000305919 ENST00000302495	P83105 [Direct mapping] Serine protease HTRA4 Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] Show all	476 aa 51 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.