Expression of PCBP1 in cancer - Summary

GENERAL INFORMATION
Gene name	PCBP1
Gene description	Poly(rC) binding protein 1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with additional nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB037113
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB037113

GENE INFORMATION
Gene name	PCBP1 (HGNC Symbol)
Synonyms	hnRNP-E1, hnRNP-X, HNRPE1, HNRPX
Description	Poly(rC) binding protein 1 (HGNC Symbol)
Entrez gene summary	This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	70087454 - 70089203
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169564 (version 83.38)
Entrez gene	5093
UniProt	Q15365 (UniProt - Evidence at protein level)
neXtProt	NX_Q15365
Antibodypedia	PCBP1 antibodies

PROTEIN BROWSER

PCBP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCBP1-001 ENSP00000305556 ENST00000303577	Q15365 [Direct mapping] Poly(rC)-binding protein 1 Q53SS8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 85; Poly(RC) binding protein 1; Putative uncharacterized protein PCBP1; cDNA, FLJ94964, highly similar to Homo sapiens poly(rC) binding protein 1 (PCBP1), mRNA Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003697 [single-stranded DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0030529 [ribonucleoprotein complex] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	356 aa 37.5 kDa	No	0