Expression of DTWD2 in cancer - Summary - The Human Protein Atlas

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DTWD2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DTWD2
Gene description	DTW domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and/or membranous expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA053173
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053173

GENE INFORMATION
Gene name	DTWD2 (HGNC Symbol)
Synonyms	FLJ33977
Description	DTW domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q23.1
Chromosome location (bp)	118837322 - 118988545
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169570 (version 83.38)
Entrez gene	285605
UniProt	Q8NBA8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NBA8
Antibodypedia	DTWD2 antibodies

PROTEIN BROWSER

DTWD2-001	DTWD2-002	DTWD2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DTWD2-001 ENSP00000425048 ENST00000510708	Q8NBA8 [Direct mapping] DTW domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	298 aa 33.4 kDa	No	0
DTWD2-002 ENSP00000424221 ENST00000515439	D6RBD8 [Direct mapping] DTW domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		202 aa 22.6 kDa	No	0
DTWD2-004 ENSP00000302892 ENST00000304058	J3KND6 [Direct mapping] DTW domain containing 2, isoform CRA_d; DTW domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		232 aa 26.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.