Expression of VPREB1 in cancer - Summary - The Human Protein Atlas

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VPREB1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	VPREB1
Gene description	Pre-B lymphocyte 1
Protein class	CD markers Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (Daudi, MOLT-4, RPMI-8226)
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear membrane expression in immune cells in hematopoietic and lymphoid tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Sub cellular location is contradicted by external data.
Reliability score	Uncertain based on 1 antibody. HPA055886
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055886

GENE INFORMATION
Gene name	VPREB1 (HGNC Symbol)
Synonyms	CD179A, VpreB
Description	Pre-B lymphocyte 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	22
Cytoband	q11.22
Chromosome location (bp)	22244675 - 22245515
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169575 (version 83.38)
Entrez gene	7441
UniProt	P12018 (UniProt - Evidence at protein level)
neXtProt	NX_P12018
Antibodypedia	VPREB1 antibodies

PROTEIN BROWSER

VPREB1-001	VPREB1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VPREB1-001 ENSP00000385361 ENST00000403807	P12018 [Direct mapping] Immunoglobulin iota chain Show all	CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002377 [immunoglobulin production] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006955 [immune response] Show all	145 aa 16.6 kDa	Yes	0
VPREB1-002 ENSP00000304590 ENST00000302273	F8W8C9 [Direct mapping] Immunoglobulin iota chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002377 [immunoglobulin production] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006955 [immune response] Show all	144 aa 16.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.