Expression of BNC1 in cancer - Summary - The Human Protein Atlas

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BNC1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	BNC1
Gene description	Basonuclin 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins Transcription factors
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (HaCaT, HBF TERT88, hTCEpi, TIME)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	BNC1 (HGNC Symbol)
Synonyms	BNC, HsT19447
Description	Basonuclin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014]
Chromosome	15
Cytoband	q25.2
Chromosome location (bp)	83255903 - 83284716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169594 (version 83.38)
Entrez gene	646
UniProt	Q01954 (UniProt - Evidence at protein level)
neXtProt	NX_Q01954
Antibodypedia	BNC1 antibodies

PROTEIN BROWSER

BNC1-001	BNC1-003	BNC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BNC1-001 ENSP00000307041 ENST00000345382	Q01954 [Direct mapping] Zinc finger protein basonuclin-1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006356 [regulation of transcription from RNA polymerase I promoter] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008284 [positive regulation of cell proliferation] GO:0008544 [epidermis development] GO:0042060 [wound healing] GO:0046872 [metal ion binding] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051276 [chromosome organization] Show all	994 aa 111 kDa	No	0
BNC1-003 ENSP00000456727 ENST00000569704	F5GY04 [Direct mapping] Zinc finger protein basonuclin-1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	987 aa 109.8 kDa	Yes	0
BNC1-201 ENSP00000478817 ENST00000618086	A0A087WUP5 [Direct mapping] Zinc finger protein basonuclin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	993 aa 111 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.