Expression of ANTXR1 in cancer - Summary - The Human Protein Atlas

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ANTXR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANTXR1
Gene description	Anthrax toxin receptor 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (LHCN-M2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Shows cytoplasmic expression in endothelial cells and positivity in plasma.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA052046
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable) and cervical cancer (unfavourable).
Thyroid cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052046

GENE INFORMATION
Gene name	ANTXR1 (HGNC Symbol)
Synonyms	ATR, FLJ10601, FLJ21776, TEM8
Description	Anthrax toxin receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	69013178 - 69249327
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169604 (version 83.38)
Entrez gene	84168
UniProt	Q9H6X2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6X2
Antibodypedia	ANTXR1 antibodies

PROTEIN BROWSER

ANTXR1-001	ANTXR1-002	ANTXR1-003	ANTXR1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANTXR1-001 ENSP00000301945 ENST00000303714	Q9H6X2 [Direct mapping] Anthrax toxin receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0022414 [reproductive process] GO:0031258 [lamellipodium membrane] GO:0031527 [filopodium membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0046872 [metal ion binding] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	564 aa 62.8 kDa	Yes	1
ANTXR1-002 ENSP00000386494 ENST00000409349	Q9H6X2 [Direct mapping] Anthrax toxin receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0031258 [lamellipodium membrane] GO:0031527 [filopodium membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0046872 [metal ion binding] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	368 aa 41.2 kDa	Yes	1
ANTXR1-003 ENSP00000387058 ENST00000409829	Q9H6X2 [Direct mapping] Anthrax toxin receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0031258 [lamellipodium membrane] GO:0031527 [filopodium membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0046872 [metal ion binding] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	333 aa 37.1 kDa	Yes	0
ANTXR1-005 ENSP00000430776 ENST00000482235	H0YC24 [Direct mapping] Anthrax toxin receptor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0016021 [integral component of membrane] Show all	179 aa 19.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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