Expression of HEXDC in cancer - Summary - The Human Protein Atlas

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HEXDC

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HEXDC
Gene description	Hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 3 antibodies. HPA022834 , HPA023379 , HPA027844
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), head and neck cancer (favourable), pancreatic cancer (favourable) and cervical cancer (favourable).
Urothelial cancer p<0.001 Head and neck cancer p<0.001 Pancreatic cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022834	HPA023379	HPA027844

GENE INFORMATION
Gene name	HEXDC (HGNC Symbol)
Synonyms	FLJ23825
Description	Hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	82418318 - 82442645
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169660 (version 83.38)
Entrez gene	284004
UniProt	Q8WVB3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WVB3
Antibodypedia	HEXDC antibodies

PROTEIN BROWSER

HEXDC-001	HEXDC-002	HEXDC-003	HEXDC-007	HEXDC-010	HEXDC-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HEXDC-001 ENSP00000337854 ENST00000337014	Q8WVB3 [Direct mapping] Hexosaminidase D Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004563 [beta-N-acetylhexosaminidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] Show all	585 aa 63.5 kDa	No	0
HEXDC-002 ENSP00000463129 ENST00000577944	J3QKL0 [Direct mapping] Hexosaminidase D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005975 [carbohydrate metabolic process] Show all	544 aa 58.4 kDa	No	0
HEXDC-003 ENSP00000332634 ENST00000327949	Q8WVB3 [Direct mapping] Hexosaminidase D Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004563 [beta-N-acetylhexosaminidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] Show all	486 aa 53.8 kDa	No	0
HEXDC-007 ENSP00000462856 ENST00000580235	J3KT84 [Direct mapping] Hexosaminidase D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005975 [carbohydrate metabolic process] Show all	118 aa 13.2 kDa	No	0
HEXDC-010 ENSP00000463625 ENST00000578632	J3QLN1 [Direct mapping] Hexosaminidase D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005975 [carbohydrate metabolic process] Show all	78 aa 8.8 kDa	No	0
HEXDC-012 ENSP00000462000 ENST00000578130	J3KRH3 [Direct mapping] Hexosaminidase D Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		214 aa 23.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.