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DRD5

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GENERAL INFORMATION

Gene name

 DRD5

Gene description

 Dopamine receptor D5

Protein class

 Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DRD5 (HGNC Symbol)

Synonyms

 DRD1B, DRD1L2

Description

 Dopamine receptor D5 (HGNC Symbol)

Entrez gene summary

 This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.1

Chromosome location (bp)

 9781680 - 9784009

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169676 (version 83.38)

Entrez gene

 1816

UniProt

 P21918 (UniProt - Evidence at protein level)

neXtProt

 NX_P21918

Antibodypedia

 DRD5 antibodies

PROTEIN BROWSER
DRD5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DRD5-001
ENSP00000306129
ENST00000304374
P21918 [Direct mapping]
D(1B) dopamine receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001588 [dopamine neurotransmitter receptor activity, coupled via Gs]
GO:0001963 [synaptic transmission, dopaminergic]
GO:0001975 [response to amphetamine]
GO:0001992 [regulation of systemic arterial blood pressure by vasopressin]
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004952 [dopamine neurotransmitter receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007612 [learning]
GO:0007617 [mating behavior]
GO:0008227 [G-protein coupled amine receptor activity]
GO:0008306 [associative learning]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0019226 [transmission of nerve impulse]
GO:0031513 [nonmotile primary cilium]
GO:0031526 [brush border membrane]
GO:0033861 [negative regulation of NAD(P)H oxidase activity]
GO:0035240 [dopamine binding]
GO:0042060 [wound healing]
GO:0042220 [response to cocaine]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045776 [negative regulation of blood pressure]
GO:0045924 [regulation of female receptivity]
GO:0046960 [sensitization]
GO:0060158 [phospholipase C-activating dopamine receptor signaling pathway]
GO:0060170 [ciliary membrane]
GO:0060292 [long term synaptic depression]
GO:0071870 [cellular response to catecholamine stimulus]
GO:0072593 [reactive oxygen species metabolic process]
Show all
 477 aa
53 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.