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BUB1

GENERAL INFORMATION

Gene name

 BUB1

Gene description

 BUB1 mitotic checkpoint serine/threonine kinase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable), endometrial cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 BUB1 (HGNC Symbol)

Synonyms

 BUB1A, BUB1L, hBUB1

Description

 BUB1 mitotic checkpoint serine/threonine kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 2

Cytoband

 q13

Chromosome location (bp)

 110637698 - 110678114

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169679 (version 83.38)

Entrez gene

 699

UniProt

 O43683 (UniProt - Evidence at protein level)

neXtProt

 NX_O43683

Antibodypedia

 BUB1 antibodies

PROTEIN BROWSER
BUB1-001
BUB1-002
BUB1-005
BUB1-006
BUB1-007
BUB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BUB1-001
ENSP00000302530
ENST00000302759
O43683 [Direct mapping]
Mitotic checkpoint serine/threonine-protein kinase BUB1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000942 [condensed nuclear chromosome outer kinetochore]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007059 [chromosome segregation]
GO:0007063 [regulation of sister chromatid cohesion]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0051301 [cell division]
GO:0051983 [regulation of chromosome segregation]
GO:0071173 [spindle assembly checkpoint]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 1085 aa
122.4 kDa 		No 0
BUB1-002
ENSP00000386701
ENST00000409311
O43683 [Direct mapping]
Mitotic checkpoint serine/threonine-protein kinase BUB1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000942 [condensed nuclear chromosome outer kinetochore]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007063 [regulation of sister chromatid cohesion]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0051301 [cell division]
GO:0051983 [regulation of chromosome segregation]
GO:0071173 [spindle assembly checkpoint]
Show all
 1028 aa
115.8 kDa 		No 0
BUB1-005
ENSP00000409713
ENST00000420328
C9JRC7 [Direct mapping]
Mitotic checkpoint serine/threonine-protein kinase BUB1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007094 [mitotic spindle assembly checkpoint]
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 134 aa
16.1 kDa 		No 0
BUB1-006
ENSP00000392219
ENST00000436916
C9IYH4 [Direct mapping]
Mitotic checkpoint serine/threonine-protein kinase BUB1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
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 56 aa
7 kDa 		No 0
BUB1-007
ENSP00000402883
ENST00000447014
C9JQA4 [Direct mapping]
Mitotic checkpoint serine/threonine-protein kinase BUB1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007094 [mitotic spindle assembly checkpoint]
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 146 aa
17.5 kDa 		No 0
BUB1-201
ENSP00000441013
ENST00000535254
O43683 [Direct mapping]
Mitotic checkpoint serine/threonine-protein kinase BUB1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000942 [condensed nuclear chromosome outer kinetochore]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007063 [regulation of sister chromatid cohesion]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0051301 [cell division]
GO:0051983 [regulation of chromosome segregation]
GO:0071173 [spindle assembly checkpoint]
Show all
 1065 aa
120 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.