Expression of SPNS1 in cancer - Summary

GENERAL INFORMATION
Gene name	SPNS1
Gene description	Spinster homolog 1 (Drosophila)
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern, highly expressed in lung macrophages and placental trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA041995 , HPA042988
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041995	HPA042988

GENE INFORMATION
Gene name	SPNS1 (HGNC Symbol)
Synonyms	HSpin1, LAT, nrs, PP2030, SPIN1, SPINL
Description	Spinster homolog 1 (Drosophila) (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	28974221 - 28984548
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169682 (version 83.38)
Entrez gene	83985
UniProt	Q9H2V7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2V7
Antibodypedia	SPNS1 antibodies

PROTEIN BROWSER

SPNS1-001	SPNS1-002	SPNS1-003	SPNS1-005	SPNS1-006	SPNS1-007	SPNS1-008	SPNS1-009	SPNS1-011	SPNS1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPNS1-001 ENSP00000309945 ENST00000311008	Q9H2V7 [Direct mapping] Protein spinster homolog 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0005515 [protein binding] GO:0005743 [mitochondrial inner membrane] GO:0005765 [lysosomal membrane] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	528 aa 56.6 kDa	No	>9
SPNS1-002 ENSP00000318228 ENST00000323081	Q9H2V7 [Direct mapping] Protein spinster homolog 1 A0A024QZ93 [Target identity:100%; Query identity:100%] Spinster, isoform CRA_f Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0005515 [protein binding] GO:0005743 [mitochondrial inner membrane] GO:0005765 [lysosomal membrane] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	455 aa 49.1 kDa	No	>9
SPNS1-003 ENSP00000454360 ENST00000565975	H3BMF4 [Direct mapping] Protein spinster homolog 1; Spinster, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	573 aa 61.1 kDa	No	>9
SPNS1-005 ENSP00000306050 ENST00000352260	Q9H2V7 [Direct mapping] Protein spinster homolog 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0005515 [protein binding] GO:0005743 [mitochondrial inner membrane] GO:0005765 [lysosomal membrane] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	454 aa 49 kDa	No	9
SPNS1-006 ENSP00000335494 ENST00000334536	Q9H2V7 [Direct mapping] Protein spinster homolog 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0005515 [protein binding] GO:0005743 [mitochondrial inner membrane] GO:0005765 [lysosomal membrane] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	476 aa 51.3 kDa	No	>9
SPNS1-007 ENSP00000456119 ENST00000566059	H3BR82 [Direct mapping] Protein spinster homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	538 aa 57.2 kDa	No	>9
SPNS1-008 ENSP00000457011 ENST00000567771	H3BT44 [Direct mapping] Protein spinster homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	178 aa 19 kDa	No	4
SPNS1-009 ENSP00000455101 ENST00000568388	H3BP14 [Direct mapping] Protein spinster homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	142 aa 15.4 kDa	No	4
SPNS1-011 ENSP00000455467 ENST00000568829	H3BPT8 [Direct mapping] Protein spinster homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] Show all	179 aa 19.6 kDa	No	3
SPNS1-012 ENSP00000455429 ENST00000564476	H3BPQ9 [Direct mapping] Protein spinster homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0006869 [lipid transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0040011 [locomotion] GO:0046624 [sphingolipid transporter activity] GO:0055085 [transmembrane transport] Show all	274 aa 29.5 kDa	No	6