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FASN

GENERAL INFORMATION

Gene name

 FASN

Gene description

 Fatty acid synthase

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in adipocytes and glandular cells of breast.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA006461 , HPA056108 , CAB005192 , CAB015417
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and renal cancer (unfavourable).
Cervical cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006461
HPA056108
CAB005192
CAB015417

GENE INFORMATION

Gene name

 FASN (HGNC Symbol)

Synonyms

 FAS, SDR27X1

Description

 Fatty acid synthase (HGNC Symbol)

Entrez gene summary

 The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 82078333 - 82098332

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169710 (version 83.38)

Entrez gene

 2194

UniProt

 P49327 (UniProt - Evidence at protein level)

neXtProt

 NX_P49327

Antibodypedia

 FASN antibodies

PROTEIN BROWSER
FASN-001
FASN-004
FASN-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FASN-001
ENSP00000304592
ENST00000306749
P49327 [Direct mapping]
Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] reductase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Enoyl-[acyl-carrier-protein] reductase Oleoyl-[acyl-carrier-protein] hydrolase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Transferases
   Hydrolases
   Lyases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001649 [osteoblast differentiation]
GO:0003824 [catalytic activity]
GO:0004312 [fatty acid synthase activity]
GO:0004313 [[acyl-carrier-protein] S-acetyltransferase activity]
GO:0004314 [[acyl-carrier-protein] S-malonyltransferase activity]
GO:0004315 [3-oxoacyl-[acyl-carrier-protein] synthase activity]
GO:0004316 [3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity]
GO:0004317 [3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity]
GO:0004319 [enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity]
GO:0004320 [oleoyl-[acyl-carrier-protein] hydrolase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0009058 [biosynthetic process]
GO:0015939 [pantothenate metabolic process]
GO:0016020 [membrane]
GO:0016295 [myristoyl-[acyl-carrier-protein] hydrolase activity]
GO:0016296 [palmitoyl-[acyl-carrier-protein] hydrolase activity]
GO:0016491 [oxidoreductase activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0019432 [triglyceride biosynthetic process]
GO:0030879 [mammary gland development]
GO:0031177 [phosphopantetheine binding]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0042470 [melanosome]
GO:0042587 [glycogen granule]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0047117 [enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity]
GO:0047451 [3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070402 [NADPH binding]
GO:0071353 [cellular response to interleukin-4]
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 2511 aa
273.4 kDa 		No 0
FASN-004
ENSP00000488964
ENST00000634990
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0031177 [phosphopantetheine binding]
GO:0055114 [oxidation-reduction process]
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 2509 aa
273.2 kDa 		No 0
FASN-007
ENSP00000489514
ENST00000635197
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
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 150 aa
16.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.