Expression of TAS2R1 in cancer - Summary - The Human Protein Atlas

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TAS2R1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TAS2R1
Gene description	Taste receptor, type 2, member 1
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA051879
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051879

GENE INFORMATION
Gene name	TAS2R1 (HGNC Symbol)
Synonyms	T2R1, TRB7
Description	Taste receptor, type 2, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	p15.31
Chromosome location (bp)	9628997 - 9712378
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169777 (version 83.38)
Entrez gene	50834
UniProt	Q9NYW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYW7
Antibodypedia	TAS2R1 antibodies

PROTEIN BROWSER

TAS2R1-001	TAS2R1-002	TAS2R1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAS2R1-001 ENSP00000371932 ENST00000382492	Q9NYW7 [Direct mapping] Taste receptor type 2 member 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family T2R receptors (taste receptor GPCRs) Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007635 [chemosensory behavior] GO:0008527 [taste receptor activity] GO:0016021 [integral component of membrane] GO:0033038 [bitter taste receptor activity] GO:0050909 [sensory perception of taste] Show all	299 aa 34.3 kDa	No	7
TAS2R1-002 ENSP00000476190 ENST00000514078	U3KQT0 [Direct mapping] Taste receptor type 2 member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0050909 [sensory perception of taste] Show all	156 aa 18.1 kDa	No	4
TAS2R1-003 ENSP00000475387 ENST00000506620	U3KPZ8 [Direct mapping] Taste receptor type 2 member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0050909 [sensory perception of taste] Show all	61 aa 7 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.