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MUC17

GENERAL INFORMATION

Gene name

 MUC17

Gene description

 Mucin 17, cell surface associated

Protein class

 Cancer-related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, small intestine)
GTEx:Tissue enriched (small intestine)
FANTOM5:Group enriched (colon, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Luminal membranous expression in small intestine.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA031634
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine)

GENE INFORMATION

Gene name

 MUC17

Synonyms

Description

 Mucin 17, cell surface associated (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 101020072 - 101058745

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169876 (version 83.38)

Entrez gene

 140453

UniProt

 Q685J3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q685J3

Antibodypedia

 MUC17 antibodies

PROTEIN BROWSER
MUC17-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MUC17-001
ENSP00000302716
ENST00000306151
Q685J3 [Direct mapping]
Mucin-17
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005796 [Golgi lumen]
GO:0005902 [microvillus]
GO:0006493 [protein O-linked glycosylation]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0030165 [PDZ domain binding]
GO:0030197 [extracellular matrix constituent, lubricant activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
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 4493 aa
451.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.