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GUSB

GENERAL INFORMATION

Gene name

 GUSB

Gene description

 Glucuronidase, beta

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA036322 , HPA036323
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036322
HPA036323

GENE INFORMATION

Gene name

 GUSB

Synonyms

Description

 Glucuronidase, beta (HGNC Symbol)

Entrez gene summary

 This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]

Chromosome

 7

Cytoband

 q11.21

Chromosome location (bp)

 65960684 - 65982314

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169919 (version 83.38)

Entrez gene

 2990

UniProt

 P08236 (UniProt - Evidence at protein level)

neXtProt

 NX_P08236

Antibodypedia

 GUSB antibodies

PROTEIN BROWSER
GUSB-001
GUSB-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GUSB-001
ENSP00000302728
ENST00000304895
P08236 [Direct mapping]
Beta-glucuronidase
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004566 [beta-glucuronidase activity]
GO:0005102 [receptor binding]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0016020 [membrane]
GO:0019391 [glucuronoside catabolic process]
GO:0019904 [protein domain specific binding]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 651 aa
74.7 kDa 		Yes 0
GUSB-002
ENSP00000391390
ENST00000421103
P08236 [Direct mapping]
Beta-glucuronidase
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004566 [beta-glucuronidase activity]
GO:0005102 [receptor binding]
GO:0005615 [extracellular space]
GO:0005975 [carbohydrate metabolic process]
GO:0006027 [glycosaminoglycan catabolic process]
GO:0016020 [membrane]
GO:0019391 [glucuronoside catabolic process]
GO:0019904 [protein domain specific binding]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030214 [hyaluronan catabolic process]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 505 aa
58.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.