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TAS1R3

GENERAL INFORMATION

Gene name

 TAS1R3

Gene description

 Taste receptor, type 1, member 3

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (epididymis, salivary gland)
GTEx:Tissue enhanced (spleen)
FANTOM5:Group enriched (epididymis, salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in several tissues, mainly in salivary gland, breast and epididymis.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA053439
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, salivary gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, salivary gland)

GENE INFORMATION

Gene name

 TAS1R3 (HGNC Symbol)

Synonyms

 T1R3

Description

 Taste receptor, type 1, member 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 1331314 - 1335306

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169962 (version 83.38)

Entrez gene

 83756

UniProt

 Q7RTX0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7RTX0

Antibodypedia

 TAS1R3 antibodies

PROTEIN BROWSER
TAS1R3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAS1R3-001
ENSP00000344411
ENST00000339381
Q7RTX0 [Direct mapping]
Taste receptor type 1 member 3
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   Family 3 (C) receptors
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0001582 [detection of chemical stimulus involved in sensory perception of sweet taste]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008527 [taste receptor activity]
GO:0016021 [integral component of membrane]
GO:0033041 [sweet taste receptor activity]
GO:0046982 [protein heterodimerization activity]
GO:0050916 [sensory perception of sweet taste]
GO:0050917 [sensory perception of umami taste]
GO:1903767 [sweet taste receptor complex]
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 852 aa
93.4 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.