Expression of MAP3K2 in cancer - Summary - The Human Protein Atlas

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MAP3K2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAP3K2
Gene description	Mitogen-activated protein kinase kinase kinase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA021540
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021540

GENE INFORMATION
Gene name	MAP3K2 (HGNC Symbol)
Synonyms	MEKK2, MEKK2B
Description	Mitogen-activated protein kinase kinase kinase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q14.3
Chromosome location (bp)	127298730 - 127388465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169967 (version 83.38)
Entrez gene	10746
UniProt	Q9Y2U5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2U5
Antibodypedia	MAP3K2 antibodies

PROTEIN BROWSER

MAP3K2-001	MAP3K2-002	MAP3K2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP3K2-001 ENSP00000387246 ENST00000409947	Q9Y2U5 [Direct mapping] Mitogen-activated protein kinase kinase kinase 2 A0A024RAH0 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase kinase kinase 2, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0019901 [protein kinase binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0071260 [cellular response to mechanical stimulus] Show all	619 aa 69.7 kDa	No	0
MAP3K2-002 ENSP00000343463 ENST00000344908	Q9Y2U5 [Direct mapping] Mitogen-activated protein kinase kinase kinase 2 A0A024RAH0 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase kinase kinase 2, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0019901 [protein kinase binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0071260 [cellular response to mechanical stimulus] Show all	619 aa 69.7 kDa	No	0
MAP3K2-003 ENSP00000386313 ENST00000409179	F8W6K3 [Direct mapping] Mitogen-activated protein kinase kinase kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0004708 [MAP kinase kinase activity] GO:0005622 [intracellular] Show all	47 aa 5.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.