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CHD3

GENERAL INFORMATION

Gene name

 CHD3

Gene description

 Chromodomain helicase DNA binding protein 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA043368
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), colorectal cancer (unfavourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001
Colorectal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043368

GENE INFORMATION

Gene name

 CHD3 (HGNC Symbol)

Synonyms

 Mi-2a, Mi2-ALPHA, ZFH

Description

 Chromodomain helicase DNA binding protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7884806 - 7912760

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170004 (version 83.38)

Entrez gene

 1107

UniProt

 Q12873 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12873

Antibodypedia

 CHD3 antibodies

PROTEIN BROWSER
CHD3-001
CHD3-002
CHD3-003
CHD3-006
CHD3-010
CHD3-011
CHD3-015
CHD3-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHD3-001
ENSP00000332628
ENST00000330494
Q12873 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 3
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007051 [spindle organization]
GO:0008026 [ATP-dependent helicase activity]
GO:0008270 [zinc ion binding]
GO:0016568 [chromatin modification]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051297 [centrosome organization]
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 2000 aa
226.6 kDa 		No 0
CHD3-002
ENSP00000350907
ENST00000358181
Q12873 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 3
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007051 [spindle organization]
GO:0008026 [ATP-dependent helicase activity]
GO:0008270 [zinc ion binding]
GO:0016568 [chromatin modification]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051297 [centrosome organization]
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 1966 aa
222.9 kDa 		No 0
CHD3-003
ENSP00000369716
ENST00000380358
Q12873 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 3
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006325 [chromatin organization]
GO:0006333 [chromatin assembly or disassembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007051 [spindle organization]
GO:0008026 [ATP-dependent helicase activity]
GO:0008270 [zinc ion binding]
GO:0016568 [chromatin modification]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051297 [centrosome organization]
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 2059 aa
233 kDa 		No 0
CHD3-006
ENSP00000405861
ENST00000452447
H7C2H0 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007051 [spindle organization]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0051297 [centrosome organization]
Show all
 525 aa
58.8 kDa 		No 0
CHD3-010
ENSP00000395252
ENST00000439235
H7C0J3 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
Show all
 383 aa
41.8 kDa 		No 0
CHD3-011
ENSP00000411959
ENST00000449744
H7C3H7 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
Show all
 277 aa
30.5 kDa 		No 0
CHD3-015
ENSP00000458861
ENST00000571249
I3L1I4 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 110 aa
11.9 kDa 		No 0
CHD3-016
ENSP00000459321
ENST00000573936
I3L229 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
Show all
 250 aa
27.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.