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Malignant tissues showed weak to moderate nuclear and occasional cytoplasmic staining. Several cases of malignant melanomas, thyroid, basal cell carcinoma and urothelial cancers exhibited strong staining. Malignant lymphomas and liver cancers were negative.
GENE INFORMATION
Gene name
CHD3 (HGNC Symbol)
Synonyms
Mi-2a, Mi2-ALPHA, ZFH
Description
Chromodomain helicase DNA binding protein 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Q12873 [Direct mapping] Chromodomain-helicase-DNA-binding protein 3
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Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q12873 [Direct mapping] Chromodomain-helicase-DNA-binding protein 3
Show all
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q12873 [Direct mapping] Chromodomain-helicase-DNA-binding protein 3
Show all
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)