Expression of ZNF778 in cancer - Summary - The Human Protein Atlas

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ZNF778

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF778
Gene description	Zinc finger protein 778
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA052057 , HPA057151
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052057	HPA057151

GENE INFORMATION
Gene name	ZNF778 (HGNC Symbol)
Synonyms	FLJ31875
Description	Zinc finger protein 778 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	89217703 - 89237071
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170100 (version 83.38)
Entrez gene	197320
UniProt	Q96MU6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MU6
Antibodypedia	ZNF778 antibodies

PROTEIN BROWSER

ZNF778-001	ZNF778-004	ZNF778-007	ZNF778-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF778-001 ENSP00000481538 ENST00000620195	Q96MU6 [Direct mapping] Zinc finger protein 778 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	729 aa 82 kDa	No	0
ZNF778-004 ENSP00000305203 ENST00000306502	Q96MU6 [Direct mapping] Zinc finger protein 778 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	687 aa 77.5 kDa	No	0
ZNF778-007 ENSP00000457800 ENST00000564906	H3BUU4 [Direct mapping] Zinc finger protein 778 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	81 aa 9.1 kDa	No	0
ZNF778-201 ENSP00000405289 ENST00000433976	A0A0A0MSW5 [Direct mapping] Zinc finger protein 778 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	757 aa 85.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.