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Moderate nuclear immunoreactivity with additional cytoplasmic staining in few cases was observed in most cancer tissues. Several gliomas were strongly stained. Few renal cancers were weakly stained or negative.
Most of the cancer tissues displayed weak to moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
ZNF778 (HGNC Symbol)
Synonyms
FLJ31875
Description
Zinc finger protein 778 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]