Expression of NIPA1 in cancer - Summary - The Human Protein Atlas

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NIPA1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NIPA1
Gene description	Non imprinted in Prader-Willi/Angelman syndrome 1
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA023269
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023269

GENE INFORMATION
Gene name	NIPA1 (HGNC Symbol)
Synonyms	MGC35570, SPG6
Description	Non imprinted in Prader-Willi/Angelman syndrome 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008]
Chromosome	15
Cytoband	q11.2
Chromosome location (bp)	22773063 - 22829791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170113 (version 83.38)
Entrez gene	123606
UniProt	Q7RTP0 (UniProt - Evidence at protein level)
neXtProt	NX_Q7RTP0
Antibodypedia	NIPA1 antibodies

PROTEIN BROWSER

NIPA1-001	NIPA1-003	NIPA1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NIPA1-001 ENSP00000337452 ENST00000337435	Q7RTP0 [Direct mapping] Magnesium transporter NIPA1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	329 aa 34.6 kDa	Yes	9
NIPA1-003 ENSP00000453722 ENST00000561183	Q7RTP0 [Direct mapping] Magnesium transporter NIPA1 A0A024R344 [Target identity:100%; Query identity:100%] Non imprinted in Prader-Willi/Angelman syndrome 1, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	254 aa 27.3 kDa	No	7
NIPA1-004 ENSP00000393962 ENST00000437912	Q7RTP0 [Direct mapping] Magnesium transporter NIPA1 A0A024R344 [Target identity:100%; Query identity:100%] Non imprinted in Prader-Willi/Angelman syndrome 1, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	254 aa 27.3 kDa	No	7

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.