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FOXD4

GENERAL INFORMATION

Gene name

 FOXD4

Gene description

 Forkhead box D4

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (THP-1)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA012836
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012836

GENE INFORMATION

Gene name

 FOXD4 (HGNC Symbol)

Synonyms

 FKHL9, FOXD4a, FREAC5

Description

 Forkhead box D4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]

Chromosome

 9

Cytoband

 p24.3

Chromosome location (bp)

 116231 - 118204

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000170122 (version 83.38)

Entrez gene

 2298

UniProt

 Q12950 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q12950

Antibodypedia

 FOXD4 antibodies

PROTEIN BROWSER
FOXD4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXD4-001
ENSP00000371940
ENST00000382500
Q12950 [Direct mapping]
Forkhead box protein D4
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008301 [DNA binding, bending]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 439 aa
47.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.