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UBE2E1

GENERAL INFORMATION

Gene name

 UBE2E1

Gene description

 Ubiquitin-conjugating enzyme E2E 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA030445
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBE2E1 (HGNC Symbol)

Synonyms

 UbcH6

Description

 Ubiquitin-conjugating enzyme E2E 1 (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 3

Cytoband

 p24.2

Chromosome location (bp)

 23805903 - 23891316

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170142 (version 83.38)

Entrez gene

 7324

UniProt

 P51965 (UniProt - Evidence at protein level)

neXtProt

 NX_P51965

Antibodypedia

 UBE2E1 antibodies

PROTEIN BROWSER
UBE2E1-001
UBE2E1-002
UBE2E1-003
UBE2E1-004
UBE2E1-006
UBE2E1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2E1-001
ENSP00000303709
ENST00000306627
P51965 [Direct mapping]
Ubiquitin-conjugating enzyme E2 E1
A0A024R2K3 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0010390 [histone monoubiquitination]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0032020 [ISG15-protein conjugation]
GO:0033523 [histone H2B ubiquitination]
GO:0042296 [ISG15 transferase activity]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
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 193 aa
21.4 kDa 		No 0
UBE2E1-002
ENSP00000329113
ENST00000346855
P51965 [Direct mapping]
Ubiquitin-conjugating enzyme E2 E1
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0010390 [histone monoubiquitination]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0032020 [ISG15-protein conjugation]
GO:0033523 [histone H2B ubiquitination]
GO:0042296 [ISG15 transferase activity]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 176 aa
19.5 kDa 		No 0
UBE2E1-003
ENSP00000411351
ENST00000424381
P51965 [Direct mapping]
Ubiquitin-conjugating enzyme E2 E1
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0010390 [histone monoubiquitination]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0032020 [ISG15-protein conjugation]
GO:0033523 [histone H2B ubiquitination]
GO:0042296 [ISG15 transferase activity]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 160 aa
18 kDa 		No 0
UBE2E1-004
ENSP00000475890
ENST00000467766
B7Z306 [Direct mapping]
Ubiquitin-conjugating enzyme E2 E1; cDNA FLJ52264, highly similar to Ubiquitin-conjugating enzyme E2 E1 (EC 6.3.2.19)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
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 167 aa
18.8 kDa 		No 0
UBE2E1-006
ENSP00000393088
ENST00000452012
H7C061 [Direct mapping]
Ubiquitin-conjugating enzyme E2 E1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
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 151 aa
16.9 kDa 		No 0
UBE2E1-007
ENSP00000410652
ENST00000442670
C9J2P0 [Direct mapping]
Ubiquitin-conjugating enzyme E2 E1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 147 aa
16.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.