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NANP

GENERAL INFORMATION

Gene name

 NANP

Gene description

 N-acetylneuraminic acid phosphatase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA050342
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050342

GENE INFORMATION

Gene name

 NANP (HGNC Symbol)

Synonyms

 C20orf147, dJ694B14.3, HDHD4, MGC26833

Description

 N-acetylneuraminic acid phosphatase (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 p11.21

Chromosome location (bp)

 25612935 - 25624175

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170191 (version 83.38)

Entrez gene

 140838

UniProt

 Q8TBE9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TBE9

Antibodypedia

 NANP antibodies

PROTEIN BROWSER
NANP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NANP-001
ENSP00000302441
ENST00000304788
Q8TBE9 [Direct mapping]
N-acylneuraminate-9-phosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006045 [N-acetylglucosamine biosynthetic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046380 [N-acetylneuraminate biosynthetic process]
GO:0050124 [N-acylneuraminate-9-phosphatase activity]
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 248 aa
27.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.