Expression of ANKK1 in cancer - Summary - The Human Protein Atlas

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ANKK1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKK1
Gene description	Ankyrin repeat and kinase domain containing 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (hTCEpi)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA012813
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012813

GENE INFORMATION
Gene name	ANKK1 (HGNC Symbol)
Synonyms	X-kinase
Description	Ankyrin repeat and kinase domain containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]
Chromosome	11
Cytoband	q23.2
Chromosome location (bp)	113387791 - 113400418
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170209 (version 83.38)
Entrez gene	255239
UniProt	Q8NFD2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NFD2
Antibodypedia	ANKK1 antibodies

PROTEIN BROWSER

ANKK1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKK1-001 ENSP00000306678 ENST00000303941	Q8NFD2 [Direct mapping] Ankyrin repeat and protein kinase domain-containing protein 1 Show all	Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	765 aa 84.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.