We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
ADRA1B
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

ADRA1B

Gene description

Adrenoceptor alpha 1B

Protein class

Cancer-related genes
FDA approved drug targets
G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (EFO-21, TIME, U-2 OS)
HPA (normal tissue):Tissue enhanced (cerebral cortex, spleen)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), thyroid cancer (favourable), endometrial cancer (unfavourable), ovarian cancer (favourable) and glioma (unfavourable).
Renal cancer p<0.001
Thyroid cancer p<0.001
Endometrial cancer p<0.001
Ovarian cancer p<0.001
Glioma p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

ADRA1B

Synonyms

Description

Adrenoceptor alpha 1B (HGNC Symbol)

Entrez gene summary

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q33.3

Chromosome location (bp)

159916783 - 159972544

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170214 (version 83.38)

Entrez gene

147

UniProt

P35368 (UniProt - Evidence at protein level)

neXtProt

NX_P35368

Antibodypedia

ADRA1B antibodies

PROTEIN BROWSER

ADRA1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRA1B-001
ENSP00000306662
ENST00000306675
P35368 [Direct mapping]
Alpha-1B adrenergic receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001974 [blood vessel remodeling]
GO:0001975 [response to amphetamine]
GO:0001987 [vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure]
GO:0001994 [norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0001996 [positive regulation of heart rate by epinephrine-norepinephrine]
GO:0001997 [positive regulation of the force of heart contraction by epinephrine-norepinephrine]
GO:0004930 [G-protein coupled receptor activity]
GO:0004937 [alpha1-adrenergic receptor activity]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0007512 [adult heart development]
GO:0007626 [locomotory behavior]
GO:0008283 [cell proliferation]
GO:0008542 [visual learning]
GO:0016021 [integral component of membrane]
GO:0016049 [cell growth]
GO:0031965 [nuclear membrane]
GO:0035265 [organ growth]
GO:0035556 [intracellular signal transduction]
GO:0042593 [glucose homeostasis]
GO:0043278 [response to morphine]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045818 [negative regulation of glycogen catabolic process]
GO:0045819 [positive regulation of glycogen catabolic process]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046982 [protein heterodimerization activity]
GO:0048148 [behavioral response to cocaine]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
520 aa
56.8 kDa
No 7

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.