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FABP6

GENERAL INFORMATION

Gene name

 FABP6

Gene description

 Fatty acid binding protein 6, ileal

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (Daudi, EFO-21)
HPA (normal tissue):Tissue enriched (small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic and membranous expression in small intestine.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA012601 , CAB024713
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012601
CAB024713

GENE INFORMATION

Gene name

 FABP6 (HGNC Symbol)

Synonyms

 I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP

Description

 Fatty acid binding protein 6, ileal (HGNC Symbol)

Entrez gene summary

 This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q33.3

Chromosome location (bp)

 160187367 - 160238735

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170231 (version 83.38)

Entrez gene

 2172

UniProt

 P51161 (UniProt - Evidence at protein level)

neXtProt

 NX_P51161

Antibodypedia

 FABP6 antibodies

PROTEIN BROWSER
FABP6-001
FABP6-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FABP6-001
ENSP00000377549
ENST00000393980
P51161 [Direct mapping]
Gastrotropin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0008206 [bile acid metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0015721 [bile acid and bile salt transport]
GO:0019433 [triglyceride catabolic process]
GO:0032052 [bile acid binding]
GO:0044281 [small molecule metabolic process]
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 177 aa
19.9 kDa 		Yes 0
FABP6-002
ENSP00000385433
ENST00000402432
P51161 [Direct mapping]
Gastrotropin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0008206 [bile acid metabolic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0015721 [bile acid and bile salt transport]
GO:0019433 [triglyceride catabolic process]
GO:0032052 [bile acid binding]
GO:0044281 [small molecule metabolic process]
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 128 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.