Expression of MRAP in cancer - Summary - The Human Protein Atlas

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MRAP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRAP
Gene description	Melanocortin 2 receptor accessory protein
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (Hep G2)
HPA (normal tissue):	Group enriched (adipose tissue, adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA011024
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011024

GENE INFORMATION
Gene name	MRAP (HGNC Symbol)
Synonyms	B27, C21orf61, FALP
Description	Melanocortin 2 receptor accessory protein (HGNC Symbol)
Entrez gene summary	This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	32291813 - 32314784
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170262 (version 83.38)
Entrez gene	56246
UniProt	Q8TCY5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCY5
Antibodypedia	MRAP antibodies

PROTEIN BROWSER

MRAP-001	MRAP-003	MRAP-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRAP-001 ENSP00000382684 ENST00000399784	Q8TCY5 [Direct mapping] Melanocortin-2 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031780 [corticotropin hormone receptor binding] GO:0031781 [type 3 melanocortin receptor binding] GO:0031782 [type 4 melanocortin receptor binding] GO:0031783 [type 5 melanocortin receptor binding] GO:0034394 [protein localization to cell surface] GO:0050873 [brown fat cell differentiation] GO:0070996 [type 1 melanocortin receptor binding] Show all	172 aa 19.1 kDa	No	1
MRAP-003 ENSP00000306697 ENST00000303645	Q8TCY5 [Direct mapping] Melanocortin-2 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031780 [corticotropin hormone receptor binding] GO:0031781 [type 3 melanocortin receptor binding] GO:0031782 [type 4 melanocortin receptor binding] GO:0031783 [type 5 melanocortin receptor binding] GO:0034394 [protein localization to cell surface] GO:0070996 [type 1 melanocortin receptor binding] Show all	172 aa 19.1 kDa	No	1
MRAP-004 ENSP00000343661 ENST00000339944	Q8TCY5 [Direct mapping] Melanocortin-2 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031780 [corticotropin hormone receptor binding] GO:0031781 [type 3 melanocortin receptor binding] GO:0031782 [type 4 melanocortin receptor binding] GO:0031783 [type 5 melanocortin receptor binding] GO:0034394 [protein localization to cell surface] GO:0070996 [type 1 melanocortin receptor binding] Show all	102 aa 11.5 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.