We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues showed weak to moderate nuclear and cytoplasmic immunoreactivity. Cases of breast cancer showed strong positivity in a fraction of cells. Renal and liver cancers were negative.
A majority of cancer tissues showed moderate to strong nuclear immunoreactivity, often accompanied with cytoplasmic staining. Prostate cancers and basal cell carcinomas showed positivity in a smaller fraction of the cells.
GENE INFORMATION
Gene name
CDK1 (HGNC Symbol)
Synonyms
CDC2, CDC28A
Description
Cyclin-dependent kinase 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Transporters Transporter channels and pores MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000187 [activation of MAPK activity] GO:0000226 [microtubule cytoskeleton organization] GO:0000278 [mitotic cell cycle] GO:0000784 [nuclear chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005876 [spindle microtubule] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007067 [mitotic nuclear division] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007098 [centrosome cycle] GO:0007344 [pronuclear fusion] GO:0007569 [cell aging] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0009636 [response to toxic substance] GO:0010243 [response to organonitrogen compound] GO:0010628 [positive regulation of gene expression] GO:0014038 [regulation of Schwann cell differentiation] GO:0014070 [response to organic cyclic compound] GO:0014075 [response to amine] GO:0014823 [response to activity] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016477 [cell migration] GO:0016572 [histone phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0030261 [chromosome condensation] GO:0030332 [cyclin binding] GO:0030496 [midbody] GO:0030544 [Hsp70 protein binding] GO:0030855 [epithelial cell differentiation] GO:0031100 [organ regeneration] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0033160 [positive regulation of protein import into nucleus, translocation] GO:0034501 [protein localization to kinetochore] GO:0035173 [histone kinase activity] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0043066 [negative regulation of apoptotic process] GO:0045471 [response to ethanol] GO:0045740 [positive regulation of DNA replication] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045995 [regulation of embryonic development] GO:0046686 [response to cadmium ion] GO:0046688 [response to copper ion] GO:0048678 [response to axon injury] GO:0051301 [cell division] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0055015 [ventricular cardiac muscle cell development] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0072686 [mitotic spindle] GO:0090166 [Golgi disassembly] GO:1900182 [positive regulation of protein localization to nucleus]
P06493 [Direct mapping] Cyclin-dependent kinase 1 A0A024QZJ8 [Target identity:100%; Query identity:100%] Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
P06493 [Direct mapping] Cyclin-dependent kinase 1 A0A024QZJ8 [Target identity:100%; Query identity:100%] Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)