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FABP4

GENERAL INFORMATION

Gene name

 FABP4

Gene description

 Fatty acid binding protein 4, adipocyte

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, cervical cancer, head and neck cancer, urothelial cancer)
HPA (cell line):Cell line enriched (RT4)
HPA (normal tissue):Tissue enriched (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in adipocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002188 , CAB024961
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, cervical cancer, head and neck cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002188
CAB024961

GENE INFORMATION

Gene name

 FABP4 (HGNC Symbol)

Synonyms

 A-FABP, aP2

Description

 Fatty acid binding protein 4, adipocyte (HGNC Symbol)

Entrez gene summary

 FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q21.13

Chromosome location (bp)

 81478419 - 81483263

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170323 (version 83.38)

Entrez gene

 2167

UniProt

 P15090 (UniProt - Evidence at protein level)

neXtProt

 NX_P15090

Antibodypedia

 FABP4 antibodies

PROTEIN BROWSER
FABP4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FABP4-001
ENSP00000256104
ENST00000256104
P15090 [Direct mapping]
Fatty acid-binding protein, adipocyte
E7DVW4 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 104; Fatty acid binding protein 4, adipocyte
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001816 [cytokine production]
GO:0005215 [transporter activity]
GO:0005504 [fatty acid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0019433 [triglyceride catabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050729 [positive regulation of inflammatory response]
GO:0050872 [white fat cell differentiation]
GO:0050873 [brown fat cell differentiation]
GO:0070062 [extracellular exosome]
GO:0071285 [cellular response to lithium ion]
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 132 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.