Cell atlas - PRDM10 - The Human Protein Atlas

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PRDM10

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleoplasm
	Vesicles

Human cell
	Nucleoli
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	PRDM10
Gene description	PR domain containing 10
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli (fibrillar center), nucleoplasm & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nucleoli fibrillar center (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA026997
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli (fibrillar center), nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Nucleoli fibrillar center (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026997	A-431	Nucleoplasm
			Nucleoli fibrillar center
			Vesicles
	HPA026997	U-2 OS	Nucleoplasm
			Nucleoli fibrillar center
			Vesicles
	HPA026997	U-251 MG	Nucleoplasm
			Nucleoli fibrillar center
			Vesicles

GENE INFORMATION
Gene name	PRDM10 (HGNC Symbol)
Synonyms	KIAA1231, MGC131802, PFM7
Description	PR domain containing 10 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q24.3
Chromosome location (bp)	129899706 - 130002835
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170325 (version 83.38)
Entrez gene	56980
UniProt	Q9NQV6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQV6
Antibodypedia	PRDM10 antibodies

PROTEIN BROWSER

PRDM10-001	PRDM10-003	PRDM10-004	PRDM10-005	PRDM10-006	PRDM10-007	PRDM10-008	PRDM10-009	PRDM10-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRDM10-001 ENSP00000354118 ENST00000360871	Q9NQV6 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	1156 aa 130.9 kDa	No	0
PRDM10-003 ENSP00000431262 ENST00000528746	E9PLV1 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0046872 [metal ion binding] Show all	1117 aa 127 kDa	No	0
PRDM10-004 ENSP00000302669 ENST00000304538	Q9NQV6 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	1023 aa 116.4 kDa	No	0
PRDM10-005 ENSP00000351686 ENST00000358825	Q9NQV6 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	1160 aa 131.3 kDa	No	0
PRDM10-006 ENSP00000398431 ENST00000423662	Q9NQV6 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	1061 aa 120.7 kDa	No	0
PRDM10-007 ENSP00000435940 ENST00000533431	E9PRS0 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	865 aa 98.2 kDa	No	0
PRDM10-008 ENSP00000432237 ENST00000526082	Q9NQV6 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	1074 aa 121.9 kDa	No	0
PRDM10-009 ENSP00000432093 ENST00000527581	E9PS52 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.3 kDa	No	0
PRDM10-010 ENSP00000436681 ENST00000531431	E9PIB4 [Direct mapping] PR domain zinc finger protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.