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B3GNT2

GENERAL INFORMATION

Gene name

 B3GNT2

Gene description

 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Protein class

 Enzymes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA005997
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005997

GENE INFORMATION

Gene name

 B3GNT2 (HGNC Symbol)

Synonyms

 B3GN-T1, B3GN-T2, B3GNT-2, B3GNT1, BETA3GNT

Description

 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p15

Chromosome location (bp)

 62196113 - 62224731

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170340 (version 83.38)

Entrez gene

 10678

UniProt

 Q9NY97 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NY97

Antibodypedia

 B3GNT2 antibodies

PROTEIN BROWSER
B3GNT2-001
B3GNT2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
B3GNT2-001
ENSP00000305595
ENST00000301998
Q9NY97 [Direct mapping]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006486 [protein glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0007411 [axon guidance]
GO:0007608 [sensory perception of smell]
GO:0008378 [galactosyltransferase activity]
GO:0008532 [N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030311 [poly-N-acetyllactosamine biosynthetic process]
GO:0042339 [keratan sulfate metabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 397 aa
46 kDa 		No 1
B3GNT2-002
ENSP00000384692
ENST00000405767
Q9NY97 [Direct mapping]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006486 [protein glycosylation]
GO:0006493 [protein O-linked glycosylation]
GO:0008378 [galactosyltransferase activity]
GO:0008532 [N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016266 [O-glycan processing]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030311 [poly-N-acetyllactosamine biosynthetic process]
GO:0042339 [keratan sulfate metabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 397 aa
46 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.