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FOS

GENERAL INFORMATION

Gene name

 FOS

Gene description

 FBJ murine osteosarcoma viral oncogene homolog

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (hTCEpi)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic staining most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018531
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (favourable).
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018531

GENE INFORMATION

Gene name

 FOS (HGNC Symbol)

Synonyms

 AP-1, c-fos

Description

 FBJ murine osteosarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

 The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 75278774 - 75282230

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170345 (version 83.38)

Entrez gene

 2353

UniProt

 P01100 (UniProt - Evidence at protein level)

neXtProt

 NX_P01100

Antibodypedia

 FOS antibodies

PROTEIN BROWSER
FOS-001
FOS-002
FOS-004
FOS-005
FOS-007
FOS-008
FOS-009
FOS-010
FOS-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOS-001
ENSP00000306245
ENST00000303562
P01100 [Direct mapping]
Proto-oncogene c-Fos
Q6FG41 [Target identity:100%; Query identity:100%]
FOS protein; V-fos FBJ murine osteosarcoma viral oncogene homolog, isoform CRA_a; cDNA FLJ76842, highly similar to Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA
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Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001661 [conditioned taste aversion]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006306 [DNA methylation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007399 [nervous system development]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0008134 [transcription factor binding]
GO:0009409 [response to cold]
GO:0009416 [response to light stimulus]
GO:0009612 [response to mechanical stimulus]
GO:0009629 [response to gravity]
GO:0009636 [response to toxic substance]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0030431 [sleep]
GO:0031668 [cellular response to extracellular stimulus]
GO:0032496 [response to lipopolysaccharide]
GO:0032570 [response to progesterone]
GO:0032870 [cellular response to hormone stimulus]
GO:0034097 [response to cytokine]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035902 [response to immobilization stress]
GO:0035914 [skeletal muscle cell differentiation]
GO:0035994 [response to muscle stretch]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051412 [response to corticosterone]
GO:0051591 [response to cAMP]
GO:0060395 [SMAD protein signal transduction]
GO:0070412 [R-SMAD binding]
GO:0071277 [cellular response to calcium ion]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Show all
 380 aa
40.7 kDa 		No 0
FOS-002
ENSP00000442268
ENST00000535987
P01100 [Direct mapping]
Proto-oncogene c-Fos
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006306 [DNA methylation]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0060395 [SMAD protein signal transduction]
GO:0070412 [R-SMAD binding]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Show all
 344 aa
36.3 kDa 		No 0
FOS-004
ENSP00000452590
ENST00000555686
P01100 [Direct mapping]
Proto-oncogene c-Fos
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006306 [DNA methylation]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0060395 [SMAD protein signal transduction]
GO:0070412 [R-SMAD binding]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Show all
 266 aa
29 kDa 		No 0
FOS-005
ENSP00000450519
ENST00000554617
G3V289 [Direct mapping]
Proto-oncogene c-Fos
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 170 aa
17.9 kDa 		No 0
FOS-007
ENSP00000452443
ENST00000554212
G3V5N9 [Direct mapping]
Proto-oncogene c-Fos
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 137 aa
15.1 kDa 		No 0
FOS-008
ENSP00000452386
ENST00000555242
G3V5J9 [Direct mapping]
Proto-oncogene c-Fos
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
Show all
 176 aa
18.9 kDa 		No 0
FOS-009
ENSP00000452440
ENST00000555672
G3V5N7 [Direct mapping]
Proto-oncogene c-Fos
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 142 aa
15.5 kDa 		No 0
FOS-010
ENSP00000451786
ENST00000557139
H0YJM3 [Direct mapping]
Proto-oncogene c-Fos
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
Show all
 83 aa
9.9 kDa 		No 0
FOS-011
ENSP00000450886
ENST00000555347
G3V2V7 [Direct mapping]
Proto-oncogene c-Fos
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
Show all
 232 aa
25 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.