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SETMAR

GENERAL INFORMATION

Gene name

 SETMAR

Gene description

 SET domain and mariner transposase fusion gene

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SETMAR (HGNC Symbol)

Synonyms

 metnase

Description

 SET domain and mariner transposase fusion gene (HGNC Symbol)

Entrez gene summary

 This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

 3

Cytoband

 p26.1

Chromosome location (bp)

 4303304 - 4317567

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170364 (version 83.38)

Entrez gene

 6419

UniProt

 Q53H47 (UniProt - Evidence at protein level)

neXtProt

 NX_Q53H47

Antibodypedia

 SETMAR antibodies

PROTEIN BROWSER
SETMAR-001
SETMAR-002
SETMAR-003
SETMAR-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SETMAR-001
ENSP00000373354
ENST00000358065
Q53H47 [Direct mapping]
Histone-lysine N-methyltransferase SETMAR Histone-lysine N-methyltransferase Transposon Hsmar1 transposase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000014 [single-stranded DNA endodeoxyribonuclease activity]
GO:0000729 [DNA double-strand break processing]
GO:0000737 [DNA catabolic process, endonucleolytic]
GO:0000793 [condensed chromosome]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006313 [transposition, DNA-mediated]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010452 [histone H3-K36 methylation]
GO:0015074 [DNA integration]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0031297 [replication fork processing]
GO:0034968 [histone lysine methylation]
GO:0035861 [site of double-strand break]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0042803 [protein homodimerization activity]
GO:0043566 [structure-specific DNA binding]
GO:0044547 [DNA topoisomerase binding]
GO:0044774 [mitotic DNA integrity checkpoint]
GO:0046975 [histone methyltransferase activity (H3-K36 specific)]
GO:0051568 [histone H3-K4 methylation]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0097676 [histone H3-K36 dimethylation]
GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
GO:2001034 [positive regulation of double-strand break repair via nonhomologous end joining]
GO:2001251 [negative regulation of chromosome organization]
Show all
 684 aa
78 kDa 		No 0
SETMAR-002
ENSP00000403000
ENST00000430981
Q53H47 [Direct mapping]
Histone-lysine N-methyltransferase SETMAR Histone-lysine N-methyltransferase Transposon Hsmar1 transposase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000014 [single-stranded DNA endodeoxyribonuclease activity]
GO:0000729 [DNA double-strand break processing]
GO:0000737 [DNA catabolic process, endonucleolytic]
GO:0000793 [condensed chromosome]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010452 [histone H3-K36 methylation]
GO:0015074 [DNA integration]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0031297 [replication fork processing]
GO:0034968 [histone lysine methylation]
GO:0035861 [site of double-strand break]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0042803 [protein homodimerization activity]
GO:0043566 [structure-specific DNA binding]
GO:0044547 [DNA topoisomerase binding]
GO:0044774 [mitotic DNA integrity checkpoint]
GO:0046975 [histone methyltransferase activity (H3-K36 specific)]
GO:0051568 [histone H3-K4 methylation]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0097676 [histone H3-K36 dimethylation]
GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
GO:2001034 [positive regulation of double-strand break repair via nonhomologous end joining]
GO:2001251 [negative regulation of chromosome organization]
Show all
 365 aa
40.5 kDa 		No 0
SETMAR-003
ENSP00000369673
ENST00000358950
B9ZVV8 [Direct mapping]
Histone-lysine N-methyltransferase SETMAR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 212 aa
23.8 kDa 		No 0
SETMAR-008
ENSP00000403145
ENST00000425863
Q53H47 [Direct mapping]
Histone-lysine N-methyltransferase SETMAR Histone-lysine N-methyltransferase Transposon Hsmar1 transposase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000014 [single-stranded DNA endodeoxyribonuclease activity]
GO:0000729 [DNA double-strand break processing]
GO:0000737 [DNA catabolic process, endonucleolytic]
GO:0000793 [condensed chromosome]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006313 [transposition, DNA-mediated]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010452 [histone H3-K36 methylation]
GO:0015074 [DNA integration]
GO:0018024 [histone-lysine N-methyltransferase activity]
GO:0031297 [replication fork processing]
GO:0034968 [histone lysine methylation]
GO:0035861 [site of double-strand break]
GO:0042800 [histone methyltransferase activity (H3-K4 specific)]
GO:0042803 [protein homodimerization activity]
GO:0043566 [structure-specific DNA binding]
GO:0044547 [DNA topoisomerase binding]
GO:0044774 [mitotic DNA integrity checkpoint]
GO:0046975 [histone methyltransferase activity (H3-K36 specific)]
GO:0051568 [histone H3-K4 methylation]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0097676 [histone H3-K36 dimethylation]
GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity]
GO:2001034 [positive regulation of double-strand break repair via nonhomologous end joining]
GO:2001251 [negative regulation of chromosome organization]
Show all
 545 aa
62.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.