Expression of CST2 in cancer - Summary - The Human Protein Atlas

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CST2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CST2
Gene description	Cystatin SA
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (RT4)
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells in salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA043706 , HPA044763 , CAB024963
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043706	HPA044763	CAB024963

GENE INFORMATION
Gene name	CST2
Synonyms
Description	Cystatin SA (HGNC Symbol)
Entrez gene summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	23823769 - 23826731
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170369 (version 83.38)
Entrez gene	1470
UniProt	P09228 (UniProt - Evidence at protein level)
neXtProt	NX_P09228
Antibodypedia	CST2 antibodies

PROTEIN BROWSER

CST2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CST2-001 ENSP00000307540 ENST00000304725	P09228 [Direct mapping] Cystatin-SA Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	141 aa 16.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.