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SP7

GENERAL INFORMATION

Gene name

 SP7

Gene description

 Sp7 transcription factor

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in seminiferous ducts of testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA063202
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA063202

GENE INFORMATION

Gene name

 SP7 (HGNC Symbol)

Synonyms

 osterix, OSX

Description

 Sp7 transcription factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 53326575 - 53345315

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170374 (version 83.38)

Entrez gene

 121340

UniProt

 Q8TDD2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDD2

Antibodypedia

 SP7 antibodies

PROTEIN BROWSER
SP7-001
SP7-002
SP7-003
SP7-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SP7-001
ENSP00000443827
ENST00000536324
Q8TDD2 [Direct mapping]
Transcription factor Sp7
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0060218 [hematopoietic stem cell differentiation]
GO:2000738 [positive regulation of stem cell differentiation]
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 431 aa
45 kDa 		No 0
SP7-002
ENSP00000302812
ENST00000303846
Q8TDD2 [Direct mapping]
Transcription factor Sp7
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0060218 [hematopoietic stem cell differentiation]
GO:2000738 [positive regulation of stem cell differentiation]
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 431 aa
45 kDa 		No 0
SP7-003
ENSP00000441367
ENST00000537210
Q8TDD2 [Direct mapping]
Transcription factor Sp7
A0A024RAY8 [Target identity:100%; Query identity:100%]
Sp7 transcription factor, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0017151 [DEAD/H-box RNA helicase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0060218 [hematopoietic stem cell differentiation]
GO:2000738 [positive regulation of stem cell differentiation]
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 413 aa
43.1 kDa 		No 0
SP7-005
ENSP00000449355
ENST00000547755
F8VV67 [Direct mapping]
Transcription factor Sp7
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Predicted intracellular proteins
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 269 aa
27 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.