Fields »
ABOUT
HELP
BLOG
SEMA3E

GENERAL INFORMATION

Gene name

 SEMA3E

Gene description

 Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SK-BR-3, U-2 OS)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA029419
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029419

GENE INFORMATION

Gene name

 SEMA3E (HGNC Symbol)

Synonyms

 coll-5, KIAA0331, M-SemaK, SEMAH

Description

 Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E (HGNC Symbol)

Entrez gene summary

 Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Chromosome

 7

Cytoband

 q21.11

Chromosome location (bp)

 83363906 - 83649010

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170381 (version 83.38)

Entrez gene

 9723

UniProt

 O15041 (UniProt - Evidence at protein level)

neXtProt

 NX_O15041

Antibodypedia

 SEMA3E antibodies

PROTEIN BROWSER
SEMA3E-001
SEMA3E-002
SEMA3E-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEMA3E-001
ENSP00000303212
ENST00000307792
O15041 [Direct mapping]
Semaphorin-3E
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001569 [patterning of blood vessels]
GO:0001755 [neural crest cell migration]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007411 [axon guidance]
GO:0008360 [regulation of cell shape]
GO:0016525 [negative regulation of angiogenesis]
GO:0030215 [semaphorin receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0038191 [neuropilin binding]
GO:0045499 [chemorepellent activity]
GO:0048843 [negative regulation of axon extension involved in axon guidance]
GO:0050808 [synapse organization]
GO:0050919 [negative chemotaxis]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 775 aa
89.2 kDa 		Yes 0
SEMA3E-002
ENSP00000405052
ENST00000427262
O15041 [Direct mapping]
Semaphorin-3E
Show all
Predicted intracellular proteins
Show all
GO:0001569 [patterning of blood vessels]
GO:0001755 [neural crest cell migration]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007411 [axon guidance]
GO:0008360 [regulation of cell shape]
GO:0016525 [negative regulation of angiogenesis]
GO:0030215 [semaphorin receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0038191 [neuropilin binding]
GO:0045499 [chemorepellent activity]
GO:0048843 [negative regulation of axon extension involved in axon guidance]
GO:0050808 [synapse organization]
GO:0050919 [negative chemotaxis]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 715 aa
82.4 kDa 		No 0
SEMA3E-004
ENSP00000412867
ENST00000442159
C9JVH5 [Direct mapping]
Semaphorin-3E
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 163 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.