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KRT8

GENERAL INFORMATION

Gene name

 KRT8

Gene description

 Keratin 8, type II

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A549, CACO-2, MCF7)
HPA (normal tissue):Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most glandular epithelia, renal tubules and pneumocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA049866 , CAB000131 , CAB001696
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA049866
CAB000131
CAB001696

GENE INFORMATION

Gene name

 KRT8 (HGNC Symbol)

Synonyms

 CARD2, CK8, CYK8, K2C8, K8, KO

Description

 Keratin 8, type II (HGNC Symbol)

Entrez gene summary

 This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52897187 - 52949954

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170421 (version 83.38)

Entrez gene

 3856

UniProt

 P05787 (UniProt - Evidence at protein level)

neXtProt

 NX_P05787

Antibodypedia

 KRT8 antibodies

PROTEIN BROWSER
KRT8-001
KRT8-002
KRT8-003
KRT8-004
KRT8-011
KRT8-013
KRT8-014
KRT8-015
KRT8-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT8-001
ENSP00000447566
ENST00000552551
P05787 [Direct mapping]
Keratin, type II cytoskeletal 8
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0097110 [scaffold protein binding]
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 483 aa
53.7 kDa 		No 0
KRT8-002
ENSP00000293308
ENST00000293308
P05787 [Direct mapping]
Keratin, type II cytoskeletal 8
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0097110 [scaffold protein binding]
Show all
 483 aa
53.7 kDa 		No 0
KRT8-003
ENSP00000447402
ENST00000546897
P05787 [Direct mapping]
Keratin, type II cytoskeletal 8
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070062 [extracellular exosome]
GO:0097110 [scaffold protein binding]
Show all
 483 aa
53.7 kDa 		No 0
KRT8-004
ENSP00000449404
ENST00000552150
P05787 [Direct mapping]
Keratin, type II cytoskeletal 8
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0005911 [cell-cell junction]
GO:0016010 [dystrophin-associated glycoprotein complex]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0030018 [Z disc]
GO:0032403 [protein complex binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0045095 [keratin filament]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045214 [sarcomere organization]
GO:0051599 [response to hydrostatic pressure]
GO:0051707 [response to other organism]
GO:0060706 [cell differentiation involved in embryonic placenta development]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0097110 [scaffold protein binding]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097284 [hepatocyte apoptotic process]
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 511 aa
56.6 kDa 		No 0
KRT8-011
ENSP00000489174
ENST00000619952
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 32 aa
4 kDa 		No 0
KRT8-013
ENSP00000447881
ENST00000546826
F8VUG2 [Direct mapping]
Keratin, type II cytoskeletal 8
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
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 273 aa
30.9 kDa 		No 0
KRT8-014
ENSP00000447040
ENST00000548998
F8W1U3 [Direct mapping]
Keratin, type II cytoskeletal 8
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
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 289 aa
32.5 kDa 		No 0
KRT8-015
ENSP00000450228
ENST00000546542
F8VQY3 [Direct mapping]
Keratin, type II cytoskeletal 8
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 180 aa
19.1 kDa 		No 0
KRT8-017
ENSP00000450340
ENST00000546900
F8VP67 [Direct mapping]
Keratin, type II cytoskeletal 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
Show all
 113 aa
13.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.