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Several squamous cell carcinomas and urothelial cancers showed weak to moderate cytoplasmic positivity. Other cancer tissues were negative.
GENE INFORMATION
Gene name
KRT78 (HGNC Symbol)
Synonyms
K5B
Description
Keratin 78, type II (HGNC Symbol)
Entrez gene summary
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]