Expression of KRT75 in cancer - Summary - The Human Protein Atlas

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KRT75

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT75
Gene description	Keratin 75, type II
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Group enriched (PC-3, U-2 OS)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in the outer root sheath of hair follicles.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. External characterization data supports antibody staining pattern while RNA data does not.
Reliability score	Supported based on 1 antibody. HPA019367
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019367

GENE INFORMATION
Gene name	KRT75 (HGNC Symbol)
Synonyms	K6HF
Description	Keratin 75, type II (HGNC Symbol)
Entrez gene summary	This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52424070 - 52434525
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170454 (version 83.38)
Entrez gene	9119
UniProt	O95678 (UniProt - Evidence at protein level)
neXtProt	NX_O95678
Antibodypedia	KRT75 antibodies

PROTEIN BROWSER

KRT75-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT75-001 ENSP00000252245 ENST00000252245	O95678 [Direct mapping] Keratin, type II cytoskeletal 75 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002244 [hematopoietic progenitor cell differentiation] GO:0005198 [structural molecule activity] GO:0005622 [intracellular] GO:0005882 [intermediate filament] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] Show all	551 aa 59.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.