Expression of DENND5B in cancer - Summary - The Human Protein Atlas

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DENND5B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DENND5B
Gene description	DENN/MADD domain containing 5B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038865
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038865

GENE INFORMATION
Gene name	DENND5B (HGNC Symbol)
Synonyms	MGC24039
Description	DENN/MADD domain containing 5B (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p11.21
Chromosome location (bp)	31382223 - 31591097
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170456 (version 83.38)
Entrez gene	160518
UniProt	Q6ZUT9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZUT9
Antibodypedia	DENND5B antibodies

PROTEIN BROWSER

DENND5B-001	DENND5B-002	DENND5B-003	DENND5B-004	DENND5B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENND5B-001 ENSP00000373734 ENST00000389082	Q6ZUT9 [Direct mapping] DENN domain-containing protein 5B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0043547 [positive regulation of GTPase activity] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	1274 aa 145 kDa	No	2
DENND5B-002 ENSP00000346238 ENST00000354285	Q6ZUT9 [Direct mapping] DENN domain-containing protein 5B Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0043547 [positive regulation of GTPase activity] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	738 aa 84 kDa	No	0
DENND5B-003 ENSP00000444889 ENST00000536562	G3V1S3 [Direct mapping] DENN domain-containing protein 5B; Uncharacterized protein Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	1309 aa 149.3 kDa	No	0
DENND5B-004 ENSP00000442938 ENST00000546299	H0YGE5 [Direct mapping] DENN domain-containing protein 5B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	537 aa 61.8 kDa	No	2
DENND5B-201 ENSP00000486530 ENST00000628277	G3V1S3 [Direct mapping] DENN domain-containing protein 5B; Uncharacterized protein Show all	MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	1309 aa 149.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.