Expression of DNAJC18 in cancer - Summary - The Human Protein Atlas

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DNAJC18

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DNAJC18
Gene description	DnaJ (Hsp40) homolog, subfamily C, member 18
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membrane expression in most tissues, including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036538
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036538

GENE INFORMATION
Gene name	DNAJC18 (HGNC Symbol)
Synonyms	MGC29463
Description	DnaJ (Hsp40) homolog, subfamily C, member 18 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q31.2
Chromosome location (bp)	139408588 - 139444491
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170464 (version 83.38)
Entrez gene	202052
UniProt	Q9H819 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H819
Antibodypedia	DNAJC18 antibodies

PROTEIN BROWSER

DNAJC18-001	DNAJC18-002	DNAJC18-003	DNAJC18-004	DNAJC18-007	DNAJC18-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNAJC18-001 ENSP00000302843 ENST00000302060	Q9H819 [Direct mapping] DnaJ homolog subfamily C member 18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	358 aa 41.6 kDa	No	1
DNAJC18-002 ENSP00000425523 ENST00000515277	D6RCS7 [Direct mapping] DnaJ homolog subfamily C member 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 19.8 kDa	No	0
DNAJC18-003 ENSP00000424572 ENST00000515581	D6RB03 [Direct mapping] DnaJ homolog subfamily C member 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		181 aa 20.8 kDa	No	0
DNAJC18-004 ENSP00000426819 ENST00000512473	D6REJ9 [Direct mapping] DnaJ homolog subfamily C member 18 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.9 kDa	No	0
DNAJC18-007 ENSP00000426338 ENST00000508445	H0YA78 [Direct mapping] DnaJ homolog subfamily C member 18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	177 aa 21.1 kDa	No	1
DNAJC18-010 ENSP00000425192 ENST00000514052	H0Y9V6 [Direct mapping] DnaJ homolog subfamily C member 18 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	121 aa 14 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.