Expression of RALGAPB in cancer - Summary - The Human Protein Atlas

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RALGAPB

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RALGAPB
Gene description	Ral GTPase activating protein, beta subunit (non-catalytic)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051454
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051454

GENE INFORMATION
Gene name	RALGAPB (HGNC Symbol)
Synonyms	DKFZp781M2411, KIAA1219, RalGAPbeta
Description	Ral GTPase activating protein, beta subunit (non-catalytic) (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	38472816 - 38578861
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170471 (version 83.38)
Entrez gene	57148
UniProt	Q86X10 (UniProt - Evidence at protein level)
neXtProt	NX_Q86X10
Antibodypedia	RALGAPB antibodies

PROTEIN BROWSER

RALGAPB-001	RALGAPB-005	RALGAPB-006	RALGAPB-008	RALGAPB-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RALGAPB-001 ENSP00000262879 ENST00000262879	Q86X10 [Direct mapping] Ral GTPase-activating protein subunit beta Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005622 [intracellular] GO:0032484 [Ral protein signal transduction] GO:0032880 [regulation of protein localization] GO:0046982 [protein heterodimerization activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0060178 [regulation of exocyst localization] GO:0061024 [membrane organization] GO:0090630 [activation of GTPase activity] Show all	1494 aa 166.8 kDa	No	0
RALGAPB-005 ENSP00000380235 ENST00000397042	Q86X10 [Direct mapping] Ral GTPase-activating protein subunit beta Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0046982 [protein heterodimerization activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0061024 [membrane organization] GO:0090630 [activation of GTPase activity] Show all	1491 aa 166.5 kDa	No	0
RALGAPB-006 ENSP00000380233 ENST00000397040	Q86X10 [Direct mapping] Ral GTPase-activating protein subunit beta Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0046982 [protein heterodimerization activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0061024 [membrane organization] GO:0090630 [activation of GTPase activity] Show all	1494 aa 166.8 kDa	No	0
RALGAPB-008 ENSP00000416646 ENST00000438490	A2A2F0 [Direct mapping] Ral GTPase-activating protein subunit beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	1323 aa 147.4 kDa	No	0
RALGAPB-010 ENSP00000487816 ENST00000632792		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	866 aa 96.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.