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KRT4

GENERAL INFORMATION

Gene name

 KRT4

Gene description

 Keratin 4, type II

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, stomach cancer, urothelial cancer)
HPA (cell line):Group enriched (HaCaT, SK-BR-3)
HPA (normal tissue):Tissue enriched (esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in non-keratinized squamous epithelia and airway epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA034881 , CAB002154
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable) and urothelial cancer (unfavourable).
Ovarian cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, stomach cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA034881
CAB002154

GENE INFORMATION

Gene name

 KRT4 (HGNC Symbol)

Synonyms

 CK4, CYK4, K4

Description

 Keratin 4, type II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52806549 - 52814551

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170477 (version 83.38)

Entrez gene

 3851

UniProt

 P19013 (UniProt - Evidence at protein level)

neXtProt

 NX_P19013

Antibodypedia

 KRT4 antibodies

PROTEIN BROWSER
KRT4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT4-001
ENSP00000448220
ENST00000551956
P19013 [Direct mapping]
Keratin, type II cytoskeletal 4
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005882 [intermediate filament]
GO:0007010 [cytoskeleton organization]
GO:0009986 [cell surface]
GO:0030855 [epithelial cell differentiation]
GO:0045095 [keratin filament]
GO:0045111 [intermediate filament cytoskeleton]
GO:0050680 [negative regulation of epithelial cell proliferation]
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 520 aa
56.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.