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NPAS2

GENERAL INFORMATION

Gene name

 NPAS2

Gene description

 Neuronal PAS domain protein 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (PC-3, RT4, U-87 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA019674
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019674

GENE INFORMATION

Gene name

 NPAS2 (HGNC Symbol)

Synonyms

 bHLHe9, MOP4, PASD4

Description

 Neuronal PAS domain protein 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 100820152 - 100996829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170485 (version 83.38)

Entrez gene

 4862

UniProt

 Q99743 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99743

Antibodypedia

 NPAS2 antibodies

PROTEIN BROWSER
NPAS2-001
NPAS2-004
NPAS2-005
NPAS2-007
NPAS2-010
NPAS2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPAS2-001
ENSP00000338283
ENST00000335681
Q99743 [Direct mapping]
Neuronal PAS domain-containing protein 2
A2I2P5 [Target identity:100%; Query identity:100%]
Neuronal PAS domain protein 2
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
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GO:0001047 [core promoter binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007417 [central nervous system development]
GO:0007623 [circadian rhythm]
GO:0032922 [circadian regulation of gene expression]
GO:0042745 [circadian sleep/wake cycle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045475 [locomotor rhythm]
GO:0045739 [positive regulation of DNA repair]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046983 [protein dimerization activity]
GO:0051775 [response to redox state]
GO:0051879 [Hsp90 protein binding]
GO:0060548 [negative regulation of cell death]
GO:2001020 [regulation of response to DNA damage stimulus]
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 824 aa
91.8 kDa 		No 0
NPAS2-004
ENSP00000397595
ENST00000427413
H7C0Z2 [Direct mapping]
Neuronal PAS domain-containing protein 2
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Predicted intracellular proteins
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
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 207 aa
23.5 kDa 		No 0
NPAS2-005
ENSP00000395265
ENST00000451740
H7C0J4 [Direct mapping]
Neuronal PAS domain-containing protein 2
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
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 107 aa
12.1 kDa 		No 0
NPAS2-007
ENSP00000388528
ENST00000448812
H7BZA3 [Direct mapping]
Neuronal PAS domain-containing protein 2
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Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
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 258 aa
29.9 kDa 		No 0
NPAS2-010
ENSP00000392125
ENST00000450763
H7BZY5 [Direct mapping]
Neuronal PAS domain-containing protein 2
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Predicted intracellular proteins
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 202 aa
21.6 kDa 		No 0
NPAS2-012
ENSP00000393396
ENST00000433408
H7C080 [Direct mapping]
Neuronal PAS domain-containing protein 2
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Predicted intracellular proteins
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 269 aa
29.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.