Expression of KRT72 in cancer - Summary - The Human Protein Atlas

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KRT72

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT72
Gene description	Keratin 72, type II
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in the hair follicle cuticle layer.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with external characterization data and GTEx RNA expression data.
Reliability score	Supported based on 1 antibody. HPA065523
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065523

GENE INFORMATION
Gene name	KRT72 (HGNC Symbol)
Synonyms	K6irs, K6IRS2, KRT6, KRT6IRS2
Description	Keratin 72, type II (HGNC Symbol)
Entrez gene summary	Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2009]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52585589 - 52601538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170486 (version 83.38)
Entrez gene	140807
UniProt	Q14CN4 (UniProt - Evidence at protein level)
neXtProt	NX_Q14CN4
Antibodypedia	KRT72 antibodies

PROTEIN BROWSER

KRT72-001	KRT72-002	KRT72-004	KRT72-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT72-001 ENSP00000441160 ENST00000537672	Q14CN4 [Direct mapping] Keratin, type II cytoskeletal 72 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005882 [intermediate filament] GO:0008150 [biological_process] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] Show all	511 aa 55.9 kDa	No	0
KRT72-002 ENSP00000346269 ENST00000354310	Q14CN4 [Direct mapping] Keratin, type II cytoskeletal 72 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005882 [intermediate filament] GO:0008150 [biological_process] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] Show all	469 aa 51.1 kDa	No	0
KRT72-004 ENSP00000449324 ENST00000549979	H0YIG3 [Direct mapping] Keratin, type II cytoskeletal 72 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	192 aa 21.7 kDa	No	0
KRT72-201 ENSP00000293745 ENST00000293745	Q14CN4 [Direct mapping] Keratin, type II cytoskeletal 72 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005882 [intermediate filament] GO:0008150 [biological_process] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] Show all	511 aa 55.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.