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PA2G4

GENERAL INFORMATION

Gene name

 PA2G4

Gene description

 Proliferation-associated 2G4, 38kDa

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA016484 , CAB011711 , CAB012428
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016484
CAB011711
CAB012428

GENE INFORMATION

Gene name

 PA2G4

Synonyms

Description

 Proliferation-associated 2G4, 38kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.2

Chromosome location (bp)

 56104319 - 56113907

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170515 (version 83.38)

Entrez gene

 5036

UniProt

 Q9UQ80 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQ80

Antibodypedia

 PA2G4 antibodies

PROTEIN BROWSER
PA2G4-001
PA2G4-008
PA2G4-009
PA2G4-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PA2G4-001
ENSP00000302886
ENST00000303305
Q9UQ80 [Direct mapping]
Proliferation-associated protein 2G4
A0A024RB85 [Target identity:100%; Query identity:100%]
Proliferation-associated 2G4, 38kDa, isoform CRA_a
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Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006364 [rRNA processing]
GO:0006417 [regulation of translation]
GO:0007049 [cell cycle]
GO:0007050 [cell cycle arrest]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0030529 [ribonucleoprotein complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070062 [extracellular exosome]
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 394 aa
43.8 kDa 		No 0
PA2G4-008
ENSP00000447615
ENST00000553057
F8W0A3 [Direct mapping]
Proliferation-associated protein 2G4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 187 aa
20.2 kDa 		No 0
PA2G4-009
ENSP00000447389
ENST00000551061
F8VZ69 [Direct mapping]
Proliferation-associated protein 2G4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 65 aa
7.3 kDa 		No 0
PA2G4-010
ENSP00000448557
ENST00000552766
F8VR77 [Direct mapping]
Proliferation-associated protein 2G4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0008283 [cell proliferation]
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 284 aa
31.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.