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PFKFB3

GENERAL INFORMATION

Gene name

 PFKFB3

Gene description

 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in mosttissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB020795
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB020795

GENE INFORMATION

Gene name

 PFKFB3

Synonyms

Description

 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 6144934 - 6235545

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170525 (version 83.38)

Entrez gene

 5209

UniProt

 Q16875 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16875

Antibodypedia

 PFKFB3 antibodies

PROTEIN BROWSER
«
PFKFB3-001
PFKFB3-002
PFKFB3-005
PFKFB3-006
PFKFB3-010
PFKFB3-011
PFKFB3-013
PFKFB3-015
PFKFB3-201
PFKFB3-202
PFKFB3-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PFKFB3-001
ENSP00000369115
ENST00000379789
Q16875 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 500 aa
57.3 kDa 		No 0
PFKFB3-002
ENSP00000369100
ENST00000379775
Q16875 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 520 aa
59.6 kDa 		No 0
PFKFB3-005
ENSP00000416677
ENST00000414237
Q9H178 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 92 aa
10 kDa 		No 0
PFKFB3-006
ENSP00000353712
ENST00000360521
Q16875 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006006 [glucose metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 514 aa
58.9 kDa 		No 0
PFKFB3-010
ENSP00000369111
ENST00000379785
Q5VX20 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 526 aa
60.3 kDa 		No 0
PFKFB3-011
ENSP00000404995
ENST00000441697
Q9BQU1 [Direct mapping]
6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0046835 [carbohydrate phosphorylation]
Show all
 31 aa
3.6 kDa 		No 0
PFKFB3-013
ENSP00000390285
ENST00000450232
H0Y483 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005524 [ATP binding]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
Show all
 143 aa
16.5 kDa 		No 0
PFKFB3-015
ENSP00000369105
ENST00000317350
Q5W015 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 513 aa
58.8 kDa 		No 0
PFKFB3-201
ENSP00000443319
ENST00000536985
Q16875 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0007420 [brain development]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 534 aa
60.6 kDa 		No 0
PFKFB3-202
ENSP00000486311
ENST00000625260
F2Z2I2 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 455 aa
52.6 kDa 		No 0
PFKFB3-203
ENSP00000487277
ENST00000626882
Q5VX20 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0008152 [metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 526 aa
60.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.