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IRX1

GENERAL INFORMATION

Gene name

 IRX1

Gene description

 Iroquois homeobox 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, glioma, testis cancer)
HPA (cell line):Group enriched (AF22, REH, U-251 MG)
HPA (normal tissue):Tissue enhanced (breast, kidney, salivary gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA043160
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, glioma, testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043160

GENE INFORMATION

Gene name

 IRX1 (HGNC Symbol)

Synonyms

 IRX-5

Description

 Iroquois homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

Chromosome

 5

Cytoband

 p15.33

Chromosome location (bp)

 3596054 - 3601403

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170549 (version 83.38)

Entrez gene

 79192

UniProt

 P78414 (UniProt - Evidence at transcript level)

neXtProt

 NX_P78414

Antibodypedia

 IRX1 antibodies

PROTEIN BROWSER
IRX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRX1-001
ENSP00000305244
ENST00000302006
P78414 [Direct mapping]
Iroquois-class homeodomain protein IRX-1
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
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GO:0001656 [metanephros development]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0072086 [specification of loop of Henle identity]
GO:0072272 [proximal/distal pattern formation involved in metanephric nephron development]
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 480 aa
49.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.