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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDH2
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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDH2

Gene description

Cadherin 2, type 1, N-cadherin (neuronal)

Protein class

CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22)
HPA (normal tissue):Tissue enhanced (heart muscle, parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in selected tissues, most abundant in liver, kidney, adrenal gland, testis and intercalated discs in heart.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA058574 , CAB000141 , CAB018580
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA058574
CAB000141
CAB018580

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas, renal and thyroid cancers along with a few cases of carcinoid, gliomas, ovarian, endometrial, lung, pancreatic and testicular cancers displayed moderate to strong membranous and/or cytoplasmic staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cases of ovarian, lung, testis, renal, hepatocellular carcinomas and gliomas showed strong cytoplasmic and membranous positivity. Remaining cancer cells were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of liver cancers and several cases of ovarian and renal cancers displayed moderate cytoplasmic and membranous positivity. Remaining cancers generally were negative or weakly stained.

GENE INFORMATION

Gene name

CDH2 (HGNC Symbol)

Synonyms

CD325, CDHN, NCAD

Description

Cadherin 2, type 1, N-cadherin (neuronal) (HGNC Symbol)

Entrez gene summary

This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

Chromosome

18

Cytoband

q12.1

Chromosome location (bp)

27950966 - 28177446

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170558 (version 83.38)

Entrez gene

1000

UniProt

P19022 (UniProt - Evidence at protein level)

neXtProt

NX_P19022

Antibodypedia

CDH2 antibodies

PROTEIN BROWSER

CDH2-001
CDH2-002
CDH2-003
CDH2-004
CDH2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH2-001
ENSP00000269141
ENST00000269141
P19022 [Direct mapping]
Cadherin-2
A0A024RC42 [Target identity:100%; Query identity:100%]
Cadherin 2, type 1, N-cadherin (Neuronal), isoform CRA_b
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005913 [cell-cell adherens junction]
GO:0005916 [fascia adherens]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007416 [synapse assembly]
GO:0008013 [beta-catenin binding]
GO:0010001 [glial cell differentiation]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0021537 [telencephalon development]
GO:0021987 [cerebral cortex development]
GO:0030027 [lamellipodium]
GO:0030864 [cortical actin cytoskeleton]
GO:0031641 [regulation of myelination]
GO:0032403 [protein complex binding]
GO:0032880 [regulation of protein localization]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0042692 [muscle cell differentiation]
GO:0043234 [protein complex]
GO:0043410 [positive regulation of MAPK cascade]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0044853 [plasma membrane raft]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045295 [gamma-catenin binding]
GO:0048514 [blood vessel morphogenesis]
GO:0048854 [brain morphogenesis]
GO:0048872 [homeostasis of number of cells]
GO:0050770 [regulation of axonogenesis]
GO:0050998 [nitric-oxide synthase binding]
GO:0051146 [striated muscle cell differentiation]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051291 [protein heterooligomerization]
GO:0060019 [radial glial cell differentiation]
GO:0060563 [neuroepithelial cell differentiation]
GO:0070062 [extracellular exosome]
GO:0070445 [regulation of oligodendrocyte progenitor proliferation]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097118 [neuroligin clustering involved in postsynaptic membrane assembly]
GO:0097150 [neuronal stem cell population maintenance]
GO:1902897 [regulation of postsynaptic density protein 95 clustering]
GO:2000809 [positive regulation of synaptic vesicle clustering]
Show all
906 aa
99.8 kDa
Yes 1
CDH2-002
ENSP00000411360
ENST00000418492
C9J8J8 [Direct mapping]
Cadherin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
Show all
191 aa
21.9 kDa
No 0
CDH2-003
ENSP00000382312
ENST00000399380
P19022 [Direct mapping]
Cadherin-2
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0008013 [beta-catenin binding]
GO:0010001 [glial cell differentiation]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016342 [catenin complex]
GO:0030027 [lamellipodium]
GO:0030864 [cortical actin cytoskeleton]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042692 [muscle cell differentiation]
GO:0044331 [cell-cell adhesion mediated by cadherin]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045295 [gamma-catenin binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0070062 [extracellular exosome]
GO:0097150 [neuronal stem cell population maintenance]
Show all
875 aa
97 kDa
No 1
CDH2-004
ENSP00000414269
ENST00000413878
C9JMH2 [Direct mapping]
Cadherin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
Show all
73 aa
8.5 kDa
No 0
CDH2-005
ENSP00000412120
ENST00000430882
C9J126 [Direct mapping]
Cadherin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
Show all
120 aa
13.8 kDa
No 0

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The Human Protein Atlas project is funded
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